ADCs consist of highly potent cytotoxic agents conjugated to antibodies through a specific linker. This molecular format enables the highly selective delivery of any payload to the diseased tissue, while healthy parts of the human body are spared. To date, ADCs generated with conventional methods have faced the following challenges:
Pre-mature loss of drug: the unstable and random attachment of the drug leads to toxicities in the healthy tissue (side-effects) and reduces overall ADC efficacy (drug does not reach target and/or poor PK), resulting in many ADC failures in clinical trials.
Limited linker solubility: payloads are often hydrophobic and thus tend to induce ADC aggregation in solution, which makes significant optimization efforts necessary for each antibody/payload combination to generate high quality ADCs.
ADC generation is time and cost-consuming due to essential and complex engineering efforts, particularly, when investigating the combination of novel payloads with existing antibodies (antibody libraries).
We are pioneering a technology enabling fast and precise production of ADCs. Our innovative approach has the potential to set new benchmarks in terms of development, analysis and performance. The following properties contribute to the high efficacy and low level of toxicity observed so far with our ADCs:
No need for engineering or antibody reduction.
This may lead to lower dosing, higher efficacy and lower risk for side effects.
As the inventor of the Araris Linker Technology, Philipp has a profound background in Bioconjugation and ADCs. He obtained his Master’s Degree and PhD from ETH Zurich at the interface of Material Science and Protein Engineering. During his post-doctoral work at PSI, he introduced the novel approach using transglutaminases for antibody conjugation that led to the discovery of the Araris Linker Technology.
Isabella holds a Master’s Degree in Molecular Biology from University of Basel and obtained a PhD in Tumorimmunology from University of Zurich (UZH). Before joining Araris, she served as Director Pharmacology at Covagen, a Swiss Biotech that was acquired in 2014 by Cilag GmbH International, an affiliate of the Janssen Pharmaceutical companies of Johnson & Johnson. She was in charge of the pharmacological characterization of various FynomAbs during pre-clinical development that entered clinical testing.
Dragan received his Master’s degree and PhD in Pharmaceutical Sciences from ETH Zürich. From 2007 to 2014 he was co-founder and CSO of Covagen, a Swiss biotech company acquired in 2014 by an affiliate of the Janssen Pharmaceutical Companies of Johnson & Johnson. He was instrumental in Covagen’s trade sale to Johnson & Johnson, in establishing deals with Roche and Mitsubishi Tanabe and in the closing of Covagen’s CHF 45M ($44.5M) Series B round in 2014. Since 2015 he is a serial entrepreneur and Biotech consultant at Grabulovski Consulting Services.
We are very proud to be chosen among 60 high quality applicants and are looking forward to the experience and learing on the roadshow in Boston.
Zedira published a high level summary on the core of the Araris Linker Technology.